DENTAL STEM CELLS

What Are Stem Cells and Dental Stem Cells?

Stem cells are responsible for the formation and development of entire system of tissues and organs. When the body reaches the adulthood, stem cells remain among mature cells for instance among skin and nerve cells. During adulthood, stem cells provide body’s natural repair and regeneration mechanism. Skin, blood and digestive cell regeneration cycles, and recovery of broken bone or regain of movement coordination after stroke are results of stem cells’ reproduction and transformation in the mature tissues.

The dentine and pulp parts of a tooth can be regenerated. It is caused by a tooth’s natural structure. Odontoblasts are functional cells of teeth. After a mild or moderate tissue damage, odontoblasts remain in the tissue and produce dentins intended for resolving the damage. However, if the damage is severe, odontoblasts will disappear. New odontoblasts are produced around the damaged area in order to protect the pulp.

Stem cells in mature pulp producing odontoblasts are first isolated in 2000 in a laboratory setting by Gronthos and his colleagues. These stem cells are named dental pulp stem cells by himself. After discovery, their ability to proliferate and differentiate is showed in the experiments on living animals and in laboratory settings.

Permanent teeth replace deciduous teeth after melting and falling out of deciduous teeth. This process occurs for 20 deciduous teeth in a span of at least 7 years. In 2002, it has been shown that the deciduous teeth contain stem cells which are also founded in permanent teeth. Stem cells had isolated from deciduous teeth have been indicated to have proliferation and differentiation properties.

Regenerative medicine aims to regenerate the functionless tissue and organs. Stem cells are the most significant regenerative factors in human body. It’s impossible to sufficiently and easily obtain stem cells from every tissue. Therefore, it’s important to keep and store deciduous and wisdom teeth as stem cell sources. In the near future, dental stem cells will have a key role in regeneration of muscle, bone, cartilage, and nervous tissues as well as ensuring reprogramming of immune system.


What Is Dental Stem Cell Banking – How Many Years Can Stem Cells Be Stored?

Dental stem cell banking aims to maintain and protect stem cells from deciduous and wisdom teeth for the future use of the owner. After teeth tissue reach our laboratory, it goes through a special progress. Initially, stem cells are isolated and proliferated, followed by freezing in liquid nitrogen (-1960 C). After the first agreement, the storage duration is 10 years, but a new contract makes it possible to extend the storage time. In this period, stem cells will keep their initial form.


From Which Teeth, Stem Cells Can Be Obtained?

It is possible to obtain stem cells from deciduous teeth of children and wisdom teeth of adolescents.

Preferably, deciduous teeth should be collected by dentists.

Extracted teeth should be immediately placed in the protective liquid that we prepared.

Teeth must be healthy, without decays. We also don’t accept the teeth from individuals having inflammatory mouth diseases.


How Does the Process Work?

Application

After a meeting between us and either the owner or the parent, we must get a written approval. This approval is the contract for the operations and storage.
Then, we will send you a kit for your dentist to place extracted teeth. The kit includes as many tubes, containing the protective liquid, as the number of teeth.

Each tooth should be put into a separate tube. Our kit has also two 10 mL anticoagulant blood tubes. At least one tube of blood is needed from the owner to be used during the cell proliferation process.


Providing the tooth origin

Deciduous and wisdom teeth should be placed in protective liquid that we will provide by the dentist extracting them in every condition; and must be sent to us within 48 hours.

Blood taken from the owner should be placed in the two 10 mL anticoagulant tubes that we will provide.


Obtaining Stem Cells from Dental Pulp Tissue

The main goal of dental stem cell banking is to store stem cells that are appropriate to use. For this reason, the pulp from the teeth we received must be isolated.

After that, the pulp tissue should be put into a special medium for reproduction of stem cells.


Quality control

Characteristic features of proliferated cells are determined. Their differentiation potentials are shown. In addition, it is indicated that they don’t carry any bacterial or fungal infections.


Storage

Identified characteristic and secure cells go under a special process and are stored in a special nitrogen tank (-196 0C). At this temperature, it’s possible to preserve cells for a long time.

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Genkord Biotechnology and Health Services are founded as an umbilical cord blood bank in 2003.

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Bağlar Mah. Yalçın Koreş Cad. Erdinç Binaları. No:22 A3 Blok Kat:1 Güneşli Bağcılar/İSTANBUL

 +90 212 231 53 50 / +90 0533 665 89 71

info@genkord.com

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